대한구강악안면외과학회
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대한구강악안면외과학회지 2009 Oct; 35(5): 353~360
비스포스포네이트로 인한 하악 및 상악골에 발생한 골괴사에 대한 임상적 연구
정혜린, 김태완, 이정근, 송승일
아주대학교 의과대학 치과학교실
대한구강악안면외과학회지 2009 Oct; 35(5): 353~360

CLINICAL STUDY OF BISPHOSPHONATE-INDUCED OSTEONECROSIS OF MANDIBULAR AND MAXILLARY BONE
Hye-Rin Joeng, Tae-Wan Kim, Jeong- Keun Lee, Seung-Il Song
Department of Dentistry, School of Medicine, Ajou University
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bisphosphonates are compounds widely used in the treatment of various metabolic and malignant bone disease. Recently, an association between bisphosphonate use and a rare dental condition termed 'osteonecrosis of the jaw(ONJ)' has been reported. Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is rare, but serious, side effect of bisphosphonate therapy in affected patients. It is characterized by poor wound healing and spontaneous intra-oral soft tissue break down, which lead to exposure of necrotic maxillary and mandibular bone. We reviewed 11 patients of BRONJ visited Ajou University Hospital Dental clinic from May 2007 to November 2008. The management of the patients included cessation of bisphosphonate therapy and various surgical restorative procedures and conservative care there after. Aggressive debridement is contraindicated. A new complication of bisphosphonate therapy administration, osteonecrosis of jaws, seems to be developing. The improved results after cessation of the medication should make clinicians reconsider the merits of the rampant use of bisphosphonates, while further investigation is needed to completely elucidate this complication.
J Korean Assoc Oral Maxillofac Surg 2009 Oct; 35(5): 353~360
Keyword : BRONJ (Bisphosphonate-related osteonecrosis of the jaw), Osteonecrosis, Osteoporosis